Crucho CIC (2014) Stimuli-responsive polymeric nanoparticles for nanomedicine. ChemMedChem 10:24–38 CrossRef Google Scholar Daglioglu C, Okutucu B (2016) Synthesis and characterization of AICAR and DOX conjugated multifunctional nanoparticles as a platform for synergistic inhibition of cancer cell growth.

However, it is still a great challenge to fabricate nanoparticles with spatiotemporally controllable delivery of anticancer drugs to tumors and with high therapeutic efficacy. This thesis mainly focuses on the development of stimuli responsive nanoparticles for cancer targeted therapy. These nanoparticles either response to internal stimuli such as

Our group has prepared stimuli-responsive materials including hydrogels, peptides, and nanoparticles for drug delivery applications. Taking this into account, stimuli responsive nanoparticles present the ability to enhance therapeutic efficacy and reduce side effects. In this review, we systematically summarized the recent progresses of controlled anti-cancer drug release systems based on nanoparticles with different stimuli response including pH, temperature, light, redox and others. 2019-03-07 Multifunctional hybrid porous silica nanoparticles for stimuli-responsive delivery of novel antimicrobial agents. PGR-P-352.

Stimuli responsive nanoparticles

responsive nanoparticles. 4. Gases. As we have seen so far, reversible, stimuli-responsive self-assembly.

"Stimuli-Responsive Gold Nanoparticles for Cancer Diagnosis and Therapy" J. Funct. 2021-03-26 We developed a stimuli-responsive clustered nanoparticle (iCluster) and justified that its adaptive alterations of physico- chemical properties (e.g.

Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy Abstract. Rheumatoid arthritis (RA) is a long-term inflammatory disease derived from an autoimmune disorder of the INTRODUCTION. Rheumatoid arthritis (RA) is a long-term inflammatory disease derived from an autoimmune

2016-01-07 · Stimuli-responsive nanoparticles (NPs) based on sustainable polymeric feedstock still need more exploration in comparison with NPs based on synthetic polymers. In this report, stimuli-responsive NPs from novel ionic cellulose derivatives were prepared via a facile nanoprecipitation.

PGR-P-352. Key facts Type of research degree PhD Application deadline Ongoing deadline Country eligibility International (open to all nationalities, including the UK) Funding Competition funded 2019-09-16 The present disclosure provides stimuli-responsive magnetic nanoparticles, methods of making the magnetic nano-particles, and methods of using the magnetic nanoparticles. The magnetic nanoparticles include a metal oxide core; and a shell that includes a stimuli-responsive polymer having a terminal group that directly coordinates to the metal oxide core.

Stimuli-responsive nanoparticles have been designed and studied, exploring their potentiality as self-assembled materials as building blocks for the development of "smart" materials for bio-applications. Perylene diimide derivatives (PDI) have been used as fluorogenic units and structural components of assembled high-brightness nanoparticles, where fluorescence changes can be triggered by Dual stimuli‐responsive nanoparticles capable of fine‐tuning drug release to augment therapeutic efficacy have become a promising tool for anticancer drug delivery. However, the rational design of these “smart” nanoparticles for a selective delivery and controlled release of multidrug combinations in cancer cells to achieve synergistic effects remain challenging. 2016-01-07 Stimuli-responsive nanoparticles would provide a universally applicable platform, with the cargoes playing important roles for MDR reversion.
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density gradient centrifugation applied on commercial gold nanoparticles example the formation of stimuli-responsive colloidal gels and colloidosomes [1]. 2689 dagar, Oral delivery of proteins by biodegradable nanoparticles. 2689 dagar, Reversal of multidrug resistance by stimuli-responsive drug delivery systems •Magnetic Nanoparticles. References / Latest synthesis of functional nanoparticles Fine-Tuning the Structure of Stimuli-Responsive Polymer Films by.

of nanoparticles typically relies on the formation of noncovalent.
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Section B focuses on selected surface reactions that lead to responsiveness achieved by decorating nanoparticles with stimuli‐responsive polymers. Although grafting‐to and grafting‐from dominate these synthetic efforts, there are opportunities for developing novel synthetic approaches facilitating controllable recognition, signaling, or sequential responses.

Abstract. Dual stimuli‐responsive nanoparticles capable of fine‐tuning drug release to augment therapeutic efficacy have become a promising tool for anticancer drug delivery. However, the rational design of these “smart” nanoparticles for a selective delivery and controlled release of multidrug combinations in cancer cells to achieve synergistic effects remain challenging. Stimuli-responsive nanoparticles would provide a universally applicable platform, with the cargoes playing important roles for MDR reversion.

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A hurdle to this goal is the inherently unfavorable tumor penetration of nanoparticles due to their relatively large sizes. We developed a stimuli- responsive

As we have seen so far, reversible, stimuli-responsive self-assembly. of nanoparticles typically relies on the formation of noncovalent. Stimuli responsive nanoparticles systems are divided into 2 classes: internal (pH, enzyme, ROS, hypoxia, redox) and external (radiation, electromagnetic, thermal) stimuli depending upon the method of inducing the delivery of the drug (Figure 1) (Taghizadeh et al., 2015; Yao et al., 2016). 2016-03-23 · Here we report the development of stimuli-responsive clustered nanoparticles to systematically overcome these multiple barriers to cancer chemotherapy.

Stimuli-responsive materials, which exhibit changes in one or more properties in response to an external trigger, have gained interest due to their tunability and versatility. Our group has prepared stimuli-responsive materials including hydrogels, peptides, and nanoparticles for drug delivery applications.

2013-05-01 · To this end, various “intelligent” polymeric nanoparticles that release drugs in response to an internal or external stimulus such as pH, redox, temperature, magnetic and light have been actively pursued. These stimuli-responsive nanoparticles have demonstrated, though to varying degrees, improved in vitro and/or in vivo drug release profiles. Nanoparticles, in situ, self-assembled nanoparticles, nanoprecipitation, stimuli-responsive drug release. ABSTRACT Nanotechnology has become an outgrowing field in novel drug delivery system. It confers several merits over conventional formulations like increased solubility and bioavailability, targeted drug delivery and a decreased dose of the Stimuli-responsive materials, which exhibit changes in one or more properties in response to an external trigger, have gained interest due to their tunability and versatility. Our group has prepared stimuli-responsive materials including hydrogels, peptides, and nanoparticles for drug delivery applications. Against this backdrop, stimuli-responsive antibiotic-loaded nanoparticles and materials with antimicrobial properties (nanoantibiotics) present the ability to enhance therapeutic efficacy, while also reducing drug resistance and side effects.

This thesis mainly focuses on the development of stimuli responsive nanoparticles for cancer targeted therapy. These nanoparticles either response to internal stimuli such as Stimuli‐responsive upconversion nanoparticles also utilize the excessive presence of adenosine triphosphate (ATP), riboflavin, and Zn 2+ in tumors. An overview of the design of stimulus‐responsive upconversion nanoparticles that precisely target and respond to tumors via targeting the tumor microenvironment and intracellular signals is provided. The stimuli-responsive nanocarriers are mainly functionalized to delivery, release and activate cargos in specific regions (e.g., tumor microenvironments or intracellular spaces of cancer cells) by responding to internal/external stimuli, e.g., pH, enzymes, etc. [ 18, 19 ], while the ligand-installed nanocarriers are mainly applied to promote the specific internalization between nanocarriers and specific cells, e.g., … Using stimuli responsive core-shell particles to produce responsive colloidosomes from emulsion templates 73.